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What is Tesamorelin and are there any side effects?

When you’re busy working out at the gym, it doesn’t take long for some dude who is ripped as hell to walk in. Surely, that can’t all be totally natural? The chances are, it’s not.

The chances are, he’s using something like Tesamorelin. But if you’re not sure what Tesamorelin is, or how it works, you’re in the right place.

Below, we’re gonna cover everything you need to know about Tesamorelin peptide, including:

  • The impact of growth hormone
  • Tesamorelin benefits
  • Potential results
  • Tesamorelin side effects

In short, Tesamorelin is a peptide, but if you’re still looking totally baffled, don’t worry, let’s dive in.

What’s a peptide?

You’ve heard of anabolic steroids, right? I doubt there’s any gym buff that hasn’t, whether they’ve used them or not. Well, peptides are somewhat similar, in the way that they enhance performance.

Peptides such as Tesamorelin have risen in popularity in recent years, and are often seen as a more natural alternative to your typical bodybuilding steroids. Many users praise the benefits of peptides – including Tesamorelin – for their ability to boost growth hormone levels, increase muscle mass and promote fat loss.

Now, let’s take a closer look at Tesamorelin in particular.

What is Tesamorelin?

Tesamorelin is a peptide that is known for triggering the secretion of growth hormone (GH). A synthetic sequence of amino acids, Tesamorelin has been designed to mimic growth hormone releasing hormone (GHRH).

GHRH is one of thousands of peptides that naturally occur in the body, playing a vital role in regulating bodily function.

Although our bodies naturally produce growth hormone, with age, this production of HGH can decrease. However, the chances are, you’re not suffering from a growth hormone deficiency.

But that doesn’t mean that a boost in GH isn’t going to benefit your workout goals.

Is Tesamorelin a growth hormone?

Tesamorelin itself is a growth hormone releasing analog, that can increase insulin like growth factor 1 levels. By binding and stimulating the GHRH receptors, it reduces visceral fat by approximately 18%, according to studies.

Furthermore, the main focus of clinical trials has been its use for HIV infected patients.

The original intention of Tesamorelin

Before being picked up by the bodybuilding community, Tesamorelin was typically prescribed to those with a growth hormone deficiency, in particular, HIV infected patients. Of course, like many other performance-enhancing drugs and steroids, Tesamorelin has become popular with bodybuilders for its power to enhance recovery times and boost muscle growth.

The reason many users look to Tesamorelin peptide and other synthetic drugs is to break through a plateau. Sometimes it can feel as though it doesn’t matter how well you eat or how often you hit the gym, some stubborn fat just won’t budge.

Often, fighting back against abdominal fat accumulation is the biggest goal for many users of Tesamorelin.

How does Tesamorelin work?

Tesamorelin peptide is a synthetic peptide, comprised of 44 amino acids – it is analogous to the growth hormone-releasing hormone (GHRH). It works to stimulate the pituitary gland in releasing GHRH.

Also Read: Cutting: How to create a calorie deficit for weight loss

Once released, it is known to promote lipolysis – the term coined for the process in which lipids and triglycerides are broken down.

Tesamorelin works to reduce excess abdominal fat, with some studies showing users seeing a drop between 15 and 17% in around 20 weeks. However, these studies have been carried out with those that have HIV-associated lipodystrophy.

Can women use Tesamorelin?

Yes, Tesamorelin a growth hormone releasing factor can be used by both men and women.

Tesamorelin peptide is not recommended for pregnant women, or those that are planning to become pregnant. If you are on diabetes medication or are borderline diabetic, you should also seek advice from a healthcare provider before using Tesamorelin.

HGH explained

Naturally produced in our bodies by the pituitary gland, HGH is incredibly important for growth, cell regeneration and cell production. It works to help maintain, build and repair healthy tissue in the brain and other organs.

As we age our natural supplies can start to dwindle. However, it is unlikely that you have a true HGH deficiency, as this is typically recognised in childhood.

Growth hormone is most prominent during childhood, supporting healthy organ, tissue and bone growth. By supporting the growth of muscle, it comes as no surprise that many of us seek synthetic growth hormone to support our fitness goals.

Since you’re here, you might want to check out our blog on natural ways to increase your GH levels.

Tesamorelin benefits

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So, what can you expect when using Tesamorelin?

With the primary purpose being to increase serum levels of growth hormone (GH), the other benefits of Tesamorelin are simply a plus.

Originally developed to treat lipodystrophy – a major symptom of HIV infected patients – Tesamorelin is renowned for burning away abdominal fat accumulation.

Here are further Tesamorelin benefits explained:

Increased GH levels

This is easily one of the biggest benefits of this peptide. So much so, that its ability to increase growth hormone is what allows the other benefits to occur, including the body’s ability to grow and repair tissue.

Fat loss

It has been shown to deliver significant weight loss, especially when it comes to abdominal fat accumulation, as well as in muscles and liver fat.

Increase muscle mass

By increasing HGH levels, it supports bodybuilders in building muscle strength, density and size.

Improved cognition

While many don’t take this peptide for this purpose individually, some research has shown it can have a positive effect on cognition.

Reduced risk of cardiac disease

Preliminary research suggests it could be beneficial in reducing the risk of cardiac disease – most likely linked to its ability to burn fat.

Stacking Tesamorelin

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At present, there are not enough studies to suggest its safety when stacking. This is most likely due to the fact that similar peptides – such as Ipamorelin – haven’t had their own clinical studies yet, so we are unaware of any drug interactions.

On the face of it, it can be stacked with Ipamorelin to achieve optimum GH releasing hormone levels. However, we wouldn’t recommend stacking it with a drug where its safety and metabolic effects are unknown.

What about other peptides?

There are plenty of peptides out there, including Ipamorelin which is often compared to Tesamorelin. What separates the two is human-based research, which Ipamorelin is yet to undergo.

However, the effects of these peptides are quite similar. Although there are some differences in structure and mechanism of action between the two.

What about Sermorelin?

Sermorelin has a short half life in comparison, with Tesamorelin also stimulating the pulsatile release of GH from the somatotrophic cells.

Where can you find Tesamorelin for sale?

Tesamorelin is available online, although we would recommend against purchasing it in this manner. However, if you are seeking a legal prescription, you will only find that doctors will prescribe it to HIV infected patients suffering from HIV-associated lipodystrophy.

In terms of price, it can vary and increase as you increase the concentration.

Dosage

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Getting the right dosage of kinda depends on what your goals are.

Also Read: The Best Steroids For Weight Loss – Steroid Comparison

Of course, either way, you’re going to be injecting yourself – so if you’re afraid of needles, it may not be for you.

Dosage for fat loss

If your aim is to shed excess abdominal fat and lose weight overall, when prescribed for lipodystrophy, this is the typical dose:

  • 2mg
  • One injection per day
  • Done at night, at least 90 minutes after eating

If your aim is bodybuilding, your dosage looks like this:

  • 1mg of Tesamorelin
  • One injection per day
  • Done at night, at least 90 minutes after eating
  • 5 days on, 2 off

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What about cognition?

Studies have shown that the following dose of Tesamorelin has proved successful for cognition:

  • 1mg of Tesamorelin
  • One injection per day
  • Done at night, 30 mins before bed
  • 5 days on, 2 off
  • For 20 weeks

In addition, Tesamorelin peptide is often used for anti-aging, as well as injury recovery. By boosting human growth hormone, this peptide can improve your skin and give the appearance of looking younger.

While it may not be the only purpose of using Tesamorelin, it can be considered a bonus.

Preparation and usage instructions:

  • Always wash your hands to prevent infection
  • Reconstitute the Tesamorelin dosage
  • Check for any discoloration or particles
  • Clean the injection site
  • Inject under the skin
  • Change the injection site for each injection to avoid issues with over-injection in one area
  • Always take it at night – This is because human growth hormone is naturally at its highest when you’re sleeping
  • Remember to always take at least 90 mins after eating – This is because food can disrupt how Tesamorelin is absorbed
  • Get into a good cycle – You need to give your body a break, which is why it’s best to do 5 days on and 2 days off

In trials across various groups of patients, it has been interesting to see the outcome and review of a Tesamorelin cycle. HIV infected patients with lipodystrophy experienced a reduction in visceral adipose tissue (VAT), but only as long as Tesamorelin peptide administration continued.

When a placebo-controlled trial was introduced, irregular fat distribution was seen again. Therefore, experts concluded that Tesamorelin should be taken across 5 days, allowing 2 days off – for 2 months, followed by a month off.

How long does it take to work?

Human-based trials suggest that its effects appear after three months, increase at six months, and are sustained for 12 months.

Is it a steroid?

No, it is a peptide.

Tesamorelin side effects

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Generally, Tesamorelin is considered a safe and well-tolerated drug. However, there are some Tesamorelin adverse effects to be aware of, reported by users:

  • Injection site reactions
  • Sweating
  • Muscle aches
  • Vomiting
  • Diarrhea
  • Frequent urination
  • Chest pain
  • A feeling of fatigue
  • Increased hunger

While some of these side effects were seen in both bodybuilding users and HIV positive patients, if you do notice the more extreme side effects, stop your cycle immediately and seek help from a healthcare provider.

Also Read: Can you speed up muscle growth?

Generally, these side effects are relatively mild for most users, and diminish after continuous administration.

It’s important to rotate the injection site, to avoid over-injecting in the same place. Of course, with increased hunger, you may find that you’re fighting with the weight loss caused by this peptide as you want to eat more.

Pros and Cons

Pros:

  • It triggers the release of GH naturally
  • Helps manage HIV infected patients suffering with HIV-associated lipodystrophy
  • Releases IGF-1 without altering blood sugar levels

Cons:

  • Needs to be taken continuously or visceral adipose tissue starts to accumulate again
  • Might increase the risk of cardiovascular diseases

Is Tesamorelin legal?

The legal status of Tesamorelin a growth hormone releasing factor can depend on where you are. In most countries, yes, it is legal to buy.

The first way to legally obtain Tesamorelin is via a prescription. However, these are only prescribed via a doctor’s approval for those suffering from lipodystrophy as a result of HIV drugs.

The other way to seek Tesamorelin is online, however, this is when purchases for research purposes.

The bottom line

With the main purpose to treat HIV infected patients, the potential side effects of Tesamorelin aren’t worth it if you ask us. While there have been a number of clinical trials regarding the effects of Tesamorelin peptide in HIV positive patients, there’s not quite enough in a bodybuilding setting.

As a synthetic growth hormone releasing factor analog, the benefits may be tempting, but there is another way to get shredded.

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The Brutal Force Team

The Brutal Force Team

We research and write articles about health, fitness and dieting. Each of our articles includes sources from scientific studies where possible.

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The Brutal Force Team

The Brutal Force Team

We research and write articles about health, fitness and dieting. Each of our articles includes sources from scientific studies where possible.