By now, you can’t step inside a gym without hearing about anabolic steroids, growth hormone and peptides – such as Sermorelin.
While it’s easy to absorb the potential benefits (as told by bodybuilders), we’re here to take a closer look into these synthetic drugs, including side effects of Sermorelin and dosage.
You will have undoubtedly heard about ‘steroids’ before now, and you may have even heard the tales of roid rage. But what are peptides? And how do they work?
What are peptides?
Peptides have risen in the ranks when it comes to performance-enhancing aids in the bodybuilding community. These short chains of amino acids are little molecules that form the building blocks of proteins, supporting muscle mass growth.
To be more specific, growth hormone secretagogues (GHS) is a type of peptide that has gained the most interest.
Often for similar reasons for using steroids and SARMs, many bodybuilders seek to alter their body fat and composition as quickly and efficiently as possible. Of course, alongside anabolic steroids comes a world of possible (and very nasty) side effects.
Some users believe that peptides – and GHSs in particular – are a more natural alternative to popular bodybuilding steroids. While also having the potential to boost muscle mass, lower body fat and enhance workout performance.
Much like the natural production of growth hormone, peptides are also naturally occurring, as well as being found in food, such as dairy, eggs, beans, meat, fish, lentils and whole grains. Although these short chains of amino acids are involved in a number of processes in the body, their support in building muscle mass is what makes them the most popular with bodybuilders.
What is Sermorelin?
Often referred to as ‘Sermorelin HGH’ ‘Sermorelin Acetate’ and ‘GRF 1-29 NH 2’, Sermorelin therapy looks to increase human growth hormone levels, promoting improved sleep quality, improved energy, higher muscle mass and lowered body fat.
However, while Sermorelin is often referred to as ‘Sermorelin HGH’, it isn’t a synthetic growth hormone. In fact, it is actually a synthetically made version of growth hormone releasing hormone (GHRH), responsible for stimulating the natural production of growth hormone.
Produced by the pituitary gland, growth hormone is a naturally occurring substance in our bodies, with very few of us actually experiencing a true human growth hormone deficiency.
Categorized as a growth hormone secretagogue, Sermorelin works by binding to the growth hormone releasing hormone receptor (GHRHr), in the pituitary gland. Here, it spikes pituitary function, promoting HGH production.
Sermorelin peptides and other peptides
Sermorelin HGH and other peptides have quickly gained a huge amount of interest from bodybuilders for stimulating growth hormone, enhancing muscle growth and helping users lose weight.
Also Read: 8 bodybuilding tips for faster results
Although, typically, the focus is around growth hormone, peptides such as Sermorelin achieve these goals in part by stimulating the liver to release insulin-like growth factor-1 (IGF-1). Then, IGF-1 works to trigger muscle protein production, helping users build muscle mass – while also promoting the breakdown of body fat.
As synthetic HGH was banned by the likes of the International Olympic Committee from 1989 onwards, users previously using HGH drugs looked to new alternatives. Since bodybuilders have explored new avenues, many claim that GHSs offer many benefits of HGH, with fewer side effects.
The most popular GHSs used for bodybuilding include:
- Growth-hormone releasing hormones: such as sermorelin, tesamorelin, CJC-1293, and CJC-1295
- Ghrelin and compounds mimicking its actions: such as lenomorelin, anamorelin, ipamorelin, macimorelin, and tabimorelin
- Growth hormone-releasing peptides (GHRPs): such as alexamorelin, GHRP-1, GHRP-2, GHRP-3, GHRP-4, GHRP-5, GHRP-6, and hexarelin
Sermorelin vs HGH
So, why should users opt for Sermorelin vs human growth hormone?
Although many users seek ‘Sermorelin HGH’, Sermorelin isn’t actually growth hormone itself. So, unlike a synthetic growth hormone drug, you’re not putting growth hormone into your body, but instead stimulating the pituitary gland and HGH production.
With HGH prohibited for off-label use, HGH therapy is typically only used in a medical setting, for conditions that may cause muscle wastage – not for bodybuilding.
If we go by this comparison of Sermorelin and synthetic HGH, Sermorelin should have fewer side effects.
By encouraging your body to produce more human growth hormone, Sermorelin stimulates natural HGH production, resulting in a variety of benefits, including:
- Increased muscle
- Increased lean body mass
- Decreased body fat
- Faster recovery after a workout and injury
- Enhanced flexibility and joint health
- Higher sleep quality
- Overall improved health
- Improved sexual performance and libido
- Increased collagen production
Administered via subcutaneous injection, Sermorelin is known for its ability to stimulate the production of IGF-1, resulting fat loss, therefore enhance lean muscle mass.
As well as helping users melt away fat to reveal lean muscle, Sermorelin shrinks recovery times so you can hit the gym sooner, while enhancing your stamina, bone mineral density and bone strength.
Since sleep plays a crucial role in weight loss and building muscle, Sermorelin’s ability to help you achieve a deep sleep also benefits your gains.
Popular safe and legal steroid and SARMs alternatives
Sermorelin and GRF 1-29: What’s the difference?
A quick search online and you’ll soon find the confusion between Sermorelin and Modified GRF 1-29. Although they are both peptides, they do have some significant differences.
While both are comprised of 29 amino acids and are similar in structure, Modified GRF 1-29 has been altered with changes to four specific amino acids in its chemical structure. These changes have been designed to increase its stability during storage, transport and administration.
Using Sermorelin and Testosterone Cypionate together
If you’re suffering from low testosterone, it is not unusual for some users of Sermorelin to combine its use with Testosterone Cypionate.
Also Read: Can you speed up muscle growth?
However, both of these require an injection. So if you’re not so keen on needles, you may want to steer clear.
Some benefits of doing so may include:
- Increased libido
- Increased HGH levels
In order to stimulate growth hormone release correctly, you need to ensure you’re hitting the right Sermorelin dosage.
Amount per administration: 200 to 1000mcg (0.25 to 1mg)
Frequency of dosage: 1 to 3 times daily
This is the most common dosage of Sermorelin, within the range of 200 to 1000mcg. Generally, the peptide is either administered once daily before bed or split into 2 – 3 smaller doses spread throughout the day.
Sermorelin half life – A shockingly short 10 to 20 minutes. Despite this, it has been shown to stimulate an acute release of growth hormone for 2 hours after administration. As a result, protocols delivering 3 daily doses of as little as 100mcg (0.1mg) per administration have been shown to cause a significant increase in GH and IGF-1 secretion.
Are there any side effects of Sermorelin?
Unfortunately, like any type of performance enhancing drug, Sermorelin does have its own set of potential side effects. The trouble is, as with anabolic steroids, there are very few clinical studies supporting their benefits.
As well as this, the lack of clinical studies means we are somewhat unaware of their short and long term side effects. When used outside of their diagnostic use, here are some of the most common side effects of Sermorelin acetate:
- Pain at the injection site
- Sleepiness (due to its impact on GH and cortisol levels)
Furthermore, drug interactions of Sermorelin may include glucocorticoid medication. With continued administration of Sermorelin, some users claimed these symptoms rapidly cleared.
However, many report pain at the injection site with use each time.
Is Sermorelin legal?
At present, the Food and Drug Administration (FDA) has only approved a handful of GHS to treat specific medical conditions via prescription only. Sermorelin and other GHSs are currently on the World Anti-Doping Agency’s list of prohibited substances.
This means that they cannot be used in competitive sport – and we wouldn’t recommend their use at all, since their safety is unknown. Despite being banned by WADA and unapproved by the FDA for use outside of medicine, GHSs are often available to purchase online without a prescription.
Are the gains worth it?
While Sermorelin peptides and other synthetic GHSs may boost muscle growth, promote fat loss and enhance your workouts, are the risks worth it? We think not.
With these drugs originally designed to treat growth hormone deficiency, using them outside of prescribed Sermorelin therapy could be dangerous. With little research into their use outside of this, we are currently clueless about potential drug interactions and other long term effects.
Why not opt for a safer way to get BIG?
Sure, you want to get BIG, get CUT and feel like you have endless energy in the gym. But is Sermorelin HGH worth it? We don’t think so.
There is a 100% legal, safe alternative though, enter: HBULK.
Get ready to level up your workouts, enhance your performance and gain quality rock-hard muscle with our fast-acting formula.